David H Gutmann Selected Research

Neurofibrosarcoma (MPNST)

7/2020	Whole exome sequencing reveals the maintained polyclonal nature from primary to metastatic malignant peripheral nerve sheath tumor in two patients with NF1.
1/2018	β-III-spectrin immunohistochemistry as a potential diagnostic tool with high sensitivity for malignant peripheral nerve sheath tumors.
1/2017	Neurofibromatosis Type 1-Associated MPNST State of the Science: Outlining a Research Agenda for the Future.
1/2017	Clinical genomic profiling identifies TYK2 mutation and overexpression in patients with neurofibromatosis type 1-associated malignant peripheral nerve sheath tumors.
10/2016	Gliosarcomas lack BRAFV600E mutation, but a subset exhibit β-catenin nuclear localization.
9/2015	Whole Exome Sequencing Reveals the Order of Genetic Changes during Malignant Transformation and Metastasis in a Single Patient with NF1-plexiform Neurofibroma.
2/2015	Morphologic and immunohistochemical features of malignant peripheral nerve sheath tumors and cellular schwannomas.
4/2011	Array-based comparative genomic hybridization identifies CDK4 and FOXM1 alterations as independent predictors of survival in malignant peripheral nerve sheath tumor.
2/2010	The neurofibromatosis type 1 tumor suppressor controls cell growth by regulating signal transducer and activator of transcription-3 activity in vitro and in vivo.
1/2010	Preclinical in vivo evaluation of rapamycin in human malignant peripheral nerve sheath explant xenograft.

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David H Gutmann Research Topics

Disease

101	Neoplasms (Cancer) 01/2022 - 04/2002
57	Glioma (Gliomas) 10/2022 - 03/2002
32	Neurofibromatosis 1 (Neurofibromatosis Type I) 01/2022 - 08/2002
24	Brain Neoplasms (Brain Tumor) 10/2022 - 03/2002
24	Optic Nerve Glioma 01/2022 - 11/2005
23	Meningioma (Meningiomas) 01/2019 - 05/2002
22	Astrocytoma (Pilocytic Astrocytoma) 01/2019 - 02/2002
22	Tuberous Sclerosis (Bourneville's Disease) 12/2017 - 06/2002
18	Neurofibrosarcoma (MPNST) 07/2020 - 03/2002
15	Neurofibromatosis 2 (Neurofibromatosis Type II) 01/2022 - 09/2002
13	Neurofibromatoses (Neurofibromatosis) 01/2022 - 08/2002
10	Neurilemmoma (Schwannoma) 02/2015 - 12/2002
8	Glioblastoma (Glioblastoma Multiforme) 12/2019 - 03/2002
8	Seizures (Absence Seizure) 12/2017 - 06/2002
7	Epilepsy (Aura) 12/2017 - 08/2003
6	Gliosis 01/2021 - 08/2003
5	Neurofibroma 01/2022 - 09/2002
5	Plexiform Neurofibroma 01/2021 - 04/2004
5	Neoplasm Metastasis (Metastasis) 11/2020 - 02/2004
5	Autistic Disorder (Autism) 11/2019 - 06/2002
5	Carcinogenesis 11/2007 - 07/2002
4	Schwannomatosis 01/2022 - 10/2008
3	Brain Diseases (Brain Disorder) 11/2019 - 10/2012
3	Neurodegenerative Diseases (Neurodegenerative Disease) 11/2019 - 03/2008
3	Hamartoma 01/2019 - 06/2002
3	Sarcoma (Soft Tissue Sarcoma) 06/2017 - 04/2011
3	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 01/2017 - 03/2008
3	Disease Progression 01/2017 - 12/2008
3	Necrosis 02/2015 - 12/2008
3	Ependymoma 01/2014 - 05/2002
3	Adenocarcinoma 05/2006 - 08/2002
2	Inflammation (Inflammations) 10/2019 - 06/2013
2	Inborn Genetic Diseases (Disease, Hereditary) 01/2018 - 12/2017
2	Hepatocellular Carcinoma (Hepatoma) 03/2012 - 05/2008
2	Learning Disabilities (Learning Disability) 10/2008 - 08/2002
2	Peripheral Nervous System Neoplasms 12/2005 - 02/2004
2	Intellectual Disability (Idiocy) 04/2004 - 06/2002
2	Focal Cortical Dysplasia 11/2003 - 06/2002
2	Central Nervous System Neoplasms 08/2002 - 05/2002

Drug/Important Bio-Agent (IBA)

45	Proteins (Proteins, Gene)FDA Link 11/2020 - 03/2002
26	Neurofibromin 1 (Neurofibromin)IBA 01/2018 - 07/2002
22	Neurofibromin 2 (Merlin)IBA 01/2014 - 05/2002
18	trans-sodium crocetinate (crocetin)IBA 12/2017 - 06/2002
14	Biomarkers (Surrogate Marker)IBA 06/2017 - 12/2004
12	Biological ProductsIBA 01/2021 - 05/2002
10	TOR Serine-Threonine KinasesIBA 10/2020 - 04/2005
8	RNA (Ribonucleic Acid)IBA 01/2022 - 06/2003
8	Pharmaceutical PreparationsIBA 05/2019 - 06/2003
7	Sirolimus (Rapamycin)FDA Link 12/2017 - 04/2008
7	ErbB Receptors (EGF Receptor)IBA 01/2017 - 03/2003
6	Retinaldehyde (Retinal)IBA 01/2019 - 09/2002
6	Small Interfering RNA (siRNA)IBA 04/2016 - 03/2006
6	DNA (Deoxyribonucleic Acid)IBA 03/2012 - 05/2002
4	MitogensIBA 01/2022 - 10/2015
4	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 01/2020 - 09/2007
4	ChemokinesIBA 01/2020 - 10/2015
4	Glial Fibrillary Acidic ProteinIBA 12/2017 - 02/2002
4	epidermal growth factor receptor VIIIIBA 01/2017 - 03/2003
4	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 06/2013 - 09/2005
4	Messenger RNA (mRNA)IBA 11/2008 - 08/2004
4	Tuberous Sclerosis Complex 2 ProteinIBA 09/2004 - 09/2002
3	CytokinesIBA 01/2021 - 01/2016
3	Transcription Factors (Transcription Factor)IBA 01/2021 - 07/2005
3	Cyclic AMP (AMP, Cyclic)IBA 10/2020 - 09/2007
3	MicroRNAs (MicroRNA)IBA 12/2019 - 01/2013
3	LigandsIBA 10/2019 - 02/2004
3	Phosphotransferases (Kinase)IBA 12/2017 - 11/2003
3	Monomeric GTP-Binding ProteinsIBA 06/2015 - 09/2002
3	Mitogen-Activated Protein KinasesIBA 01/2015 - 06/2003
3	RolipramIBA 07/2010 - 10/2008
3	OligonucleotidesIBA 03/2006 - 08/2002
3	Tumor Suppressor Proteins (Proteins, Tumor Suppressor)IBA 11/2004 - 08/2003
2	Neutralizing AntibodiesIBA 01/2022 - 10/2015
2	Uvitex SWN (SWN)IBA 01/2022 - 06/2017
2	Glycoproteins (Glycoprotein)IBA 10/2021 - 10/2019
2	NestinIBA 01/2021 - 01/2005
2	Everolimus FDA Link 01/2021 - 10/2020
2	MTOR InhibitorsIBA 10/2020 - 02/2015
2	CC ChemokinesIBA 10/2019 - 10/2015
2	SpectrinIBA 01/2018 - 09/2015
2	Indicators and Reagents (Reagents)IBA 03/2015 - 12/2013
2	Dopamine (Intropin)FDA LinkGeneric 02/2014 - 04/2013
2	Proto-Oncogene Proteins B-rafIBA 10/2013 - 12/2012
2	Anticonvulsants (Antiepileptic Drugs)IBA 10/2013 - 08/2007
2	Superoxide DismutaseIBA 01/2011 - 03/2008
2	Hormones (Hormone)IBA 08/2010 - 09/2002
2	Progesterone Receptors (Progesterone Receptor)IBA 08/2010 - 12/2004
2	H-cadherin (T-cadherin)IBA 05/2008 - 01/2003
2	ManganeseIBA 03/2008 - 05/2007
2	Glutamic Acid (Glutamate)FDA Link 11/2007 - 08/2003
2	Tumor Suppressor Protein p14ARF (p14ARF)IBA 03/2006 - 11/2004
2	RNA-Directed DNA Polymerase (Reverse Transcriptase)IBA 12/2005 - 08/2002
2	GTPase-Activating Proteins (GTPase-Activating Protein)IBA 04/2005 - 01/2003
2	Cell Adhesion Molecule-1IBA 12/2004 - 10/2004
2	Growth Factor ReceptorsIBA 04/2004 - 09/2002
1	Cyclic NucleotidesIBA 01/2022
1	alpha2 Subunit Collagen Type IIBA 01/2022

Therapy/Procedure

55	Therapeutics 10/2022 - 03/2002
12	Drug Therapy (Chemotherapy) 01/2022 - 12/2004
2	Aftercare (After-Treatment) 01/2021 - 12/2020